One of the fundamental questions in cancer research asks why patients treated for some types of cancer develop a resistance to chemotherapy drugs. Drs. Susan Cole and Roger Deeley showed that a multidrug resistant protein (MRP) is a factor. It prevents chemotherapy from working by pumping the drugs out of cancer cells. The Queen’s University researchers discovered the gene that codes for MRP, giving drug researchers a target for solving the problem.
Their paradigm-shifting discovery led to a subsequent explosion in research on multidrug resistance in humans and other animals. MRP is Queen’s most-licensed (28x) technology to date.